翻訳と辞書 Words near each other ・ N,N'-Diisopropylcarbodiimide ・ N,N'-Methylenebisacrylamide ・ N,N-Diisopropylaminoethanol ・ N,N-Diisopropylethylamine ・ N,N-Dimethyl-1-naphthylamine ・ N,N-Dimethyldopamine ・ N,N-Dimethylethylamine ・ N,N-dimethylformamidase ・ N,N-Dimethylsphingosine ・ N,N-Dimethyltryptamine ・ N,N′-Dimethyl-1,3-propanediamine ・ N,O-Dimethyl-4-(2-naphthyl)piperidine-3-carboxylate ・ N,O-Dimethylhydroxylamine ・ N- ・ N-(1-Naphthyl)ethylenediamine ・ N-(2-Hydroxypropyl) methacrylamide ・ N-(long-chain-acyl)ethanolamine deacylase ・ N-(p-amylcinnamoyl)anthranilic acid ・ N-(S)-Fenchyl-1-(2-morpholinoethyl)-7-methoxyindole-3-carboxamide ・ N-105 National Highway ・ N-110 National Highway ・ N-110 road (Spain) ・ N-111 road (Spain) ・ N-113 road (Spain) ・ N-120 National Highway ・ N-120 road (Spain) ・ N-121 road (Spain) ・ N-122 road (Spain) ・ N-123 road (Spain) ・ N-124 road (Spain) Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク N-(2-Hydroxypropyl) methacrylamide ： ウィキペディア英語版 N-(2-Hydroxypropyl) methacrylamide }} ''N''-(2-Hydroxypropyl)methacrylamide or HPMA is the monomer used to make the polymer poly(''N''-(2-hydroxypropyl)methacrylamide). The polymer is water-soluble (highly hydrophilic), non-immunogenic and non-toxic, and resides in the blood circulation well. Thus, it is frequently used as macromolecular carriers for low molecular weight drugs (especially anti-cancer chemotherapeutic agents) to enhance therapeutic efficacy and limit side effects.〔(HPMA copolymers: 30 years of advances )〕 Poly(HPMA)-drug conjugate preferably accumulates in tumor tissues via the passive-targeting process (or so-called EPR effect). Due to its favorable characteristics, HPMA polymers and copolymers are also commonly used to produce synthetic biocompatible medical materials such as hydrogels. The development of pHPMA as anti-cancer drug delivery vehicles is initiated by Dr. Jindřich Kopeček and colleagues at the Czech (-oslovak) Academy of Sciences in Prague in the mid-1970s.〔(HPMA copolymers: Origins, early developments, present, and future )〕 Prior to this, it was used as a plasma expander. The Kopeček Laboratory designed and developed HPMA copolymer-drug conjugates as a lysosomal delivery vehicle to cancer cells. The concept of using pHPMA as polymeric drug carriers has opened a new perspective in modern pharmaceutical science, and developed into the first polymer-drug conjugate entering clinical trials (''i.e.'' PK1; HPMA copolymer-doxorubicin conjugate).〔(Clinical Cancer Research Vol. 5, 83–94, January 1999 )〕 == References == 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「N-(2-Hydroxypropyl) methacrylamide」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.